Follows the adventures of nine-year-old Ramona at home with big sister Beezus and baby sister Roberta, and at school in Mrs. Meacham's fourth grade class.

In his letters to his favorite author, ten-year-old Leigh reveals his problems in coping with his parents' divorce, being the new boy in school, and generally finding his own place in the world.

A troublemaker meets his match when he pushes the quietest girl in the class too far.

Ramona starts kindergarten where her good intentions and uncontrollable curiosity lead her to be labeled a pest.