Ramona is a little girl with a very big imagination and a nose for mischief. Her playful antics keep everyone in her loving family on their toes, including her older sister Beezus, who's just trying to survive her first year of high school. Through all the ups and downs of childhood, Ramona and Beezus learn that anything's possible when you believe in yourself and rely on each other. Based on the best-selling books by Beverly Cleary.

Follows the adventures of nine-year-old Ramona at home with big sister Beezus and baby sister Roberta, and at school in Mrs. Meacham's fourth grade class.

The further adventures of the Quimby family as Ramona enters the third grade.