With their elite organization shut down by the CIA, agent Ethan Hunt and his team must race against time to stop The Syndicate, a deadly network of rogue operatives turned traitors. To stop this global threat, Ethan must join forces with an elusive, disavowed agent whose loyalty is suspect as he faces his most impossible mission ever.

As a CIA officer, Evelyn Salt swore an oath to duty, honor and country. Her loyalty will be tested when a defector accuses her of being a Russian spy. Salt goes on the run, using all her skills and years of experience as a covert operative to elude capture. Her efforts to prove her innocence only serve to cast doubt on her motives, as the hunt to uncover the truth behind her identity continues.