Franny K. Stein has had quite enough of her feelings getting in the way. So she physically removes them with the help of one of her machines. But it turns out that not having feelings can make things even worse, especially when you've accidentally released a virus that's turning everybody into toads. Good thing she has the help of her grandma, Granny Fran, and her Sense of Duty to help her shake the apathy.

Franny tries to follow her mother's suggestion to change her appearance, but by turning hair styling into a science experiment she creates some very greedy pigtails that terrorize the town.

Concerned that the fundraisers for the school art and music departments are not doing well, Franny K. Stein creates in her laboratory/kitchen an irresistible muffin recipe.

Frannie tries to prevent chaos when her new lab assistant, Igor, a dog of many breeds, accidentally lets loose a giant, fifty-foot, arrow-shooting cupid.